Centro de Biologia Molecular e Ambiental

Centre of Molecular and Environmental Biology


Protein Degradation and Trafficking in Health and Disease (2nd Edition)

Dates & Venue
25 April - 6 May 

The lectures, in the scope of the "1st Small Meeting on Endocytic Trafficking and Signaling - SMTES1", will take place at INL (International Iberian Nanotechnology Laboratory). 
The practical sessions will take place at the Department of Biology, School of Sciences, University of Minho, Campus de Gualtar.
Scop of the course

This course is organized for post-graduation students or researchers and it will focus on the mechanisms of protein degradation and trafficking in different organisms and their mode of signalling and regulation. Several human diseases, including cancer and neurodegenerative diseases result when the regulation of trafficking events is not fully operating. A panel of world-wide recognized experts will be involved in the lecturing of this advanced course. It will provide seminars and lectures on very diverse aspects of this research area. Several molecular, biochemical and bioinformatic techniques will also be addressed in the practical sessions to study these processes.


Alexander Sorkin 
University of Pittsburgh, USA
Christopher G. Burd 
Yale University, USA
David Drubin
UC Berkeley, USA
Duarte Barral
Nova University of Lisbon, Portugal
Georjana Barnes 
UC Berkeley, USA
Henrique Girão
University of Coimbra, Portugal
Hernâni Gerós 
University of Minho, Portugal
Isabel Soares-Silva
University of Porto, Faculty of Medicine, Portugal
Jorge Azevedo
University of Porto, Portugal
Margarida Casal
University of Minho, Portugal
Olivier Vincent
IIB-CSIC Madrid, Spain
Patrícia Maciel  
University of Minho, Portugal
Sandra Paiva
University of Minho, Portugal

Sandra Paiva (Chair)
Cláudia Barata 
Gabriel Talaia
Rosana Alves

Artur ribeiro
Cláudia Barata
Gabriel Talaia
Isabel Soares-Silva
Rosana Alves
Sandra Paiva



The following topics will be covered: endocytic and exocytic mechanisms, retrograde sorting, Rab Regulation in membrane trafficking, the ESCRT pathway, SUMO and ubiquitin. The praticals will focus on:

. Use of protein tags to study protein trafficking 
. Ubiquitylation in vivo and in vitro (yeast and mammalian cells)
. Bioinformatical approaches to study endocytosis

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