CBMA

Centro de Biologia Molecular e Ambiental

Centre of Molecular and Environmental Biology

Mammalian and yeast as complementary cell models in Programmed Cell Death - 5th edition

Dates & Venue
June 23 to 4 July
Departament of Biology, Universidade do Minho
Invited Lecturers
Cecília Rodrigues
Molecular Pathogenesis Centre, Faculty of Pharmacy, University of Porto, Portugal
Helena Vasconcelos Meehan
Faculty of Pharmacy and IPATIMUP, University of Porto
Muriel Priault
CNRS-Université de Bordeaux, France
Nadine Camougrand
CNRS-Université de Bordeaux, France
Stéphen Manon
CNRS-Université de Bordeaux, France
Vítor Costa
IBMC, University of Porto

In-House
Lecturers
Ana Preto
CBMA-DB, University of Minho, Portugal
António Rego
CBMA-DB, University of Minho, Portugal
Manuela Côrte-Real
CBMA-DB, University of Minho, Portugal
Maria João Sousa
CBMA-DB, University of Minho, Portugal
Susana Chaves
CBMA-DB, University of Minho, Portugal

Topics
  • Programmed Cell Death processes versus necrosis
  • Apoptosis and programmed necrosis
  • Acetic acid/acetate-induced apoptosis in yeast and mammalian cell
  • Features of cell death in human disease
  • Evasion from programmed cell death in cancer and in cancer drug resisitance. Pharmacological modulation of apoptosis as a therapeutic approach
  • Yeast as a model system to study mechanisms of apoptosis induced by anti-tumour drugs
  • Sphingolipid signalling and oxidative stress in yeast cell death and ageing
  • Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism
  • Mitochondrial membrane permeabilization mechanisms
  • Utilization of yeast to study the molecular aspects of the function of Bcl-2 family members
  • Autophagy in physiology and pathology
  • Mitophagy: from yeasts to mammalian cells
  • The role of autophagy in cancer: the special case of oncogene KRAS and colorectal carcinoma
Pratical session
tutors
Carla Lopes
CBMA-DB, University of Minho, Portugal
Cátia Pereira
CBMA-DB, University of Minho, Portugal
Júlia Santos
CBMA-DB, University of Minho, Portugal
Sara Alves
CBMA-DB, University of Minho, Portugal
Suellen Ferro
CBMA-DB, University of Minho, Portugal

Course includes theoretical lectures and hands-on intensive module of lab work that will be followed by results interpretation, group discussion and final wrap up.

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