CBMA

Centro de Biologia Molecular e Ambiental

Centre of Molecular and Environmental Biology

 

Plasma Membrane transporters: Physiology, Genetics and Phylogeny (5th edition)

Dates & Venue
June 2 - 14
Departament of Biology, University of Minho
Course Info

A multidisciplinary approach will be undertaken in this course to cover and explore the following major subjects: cellular transport mechanisms, kinetics and energetics; transport mechanisms characterization, gene expression and regulation; carriers and channels in bacteria, yeast, animal and plant cells; biogenesis of transport proteins, trafficking of plasma membrane proteins along the endocytic pathway; structural-functional analysis of transporters; the role of transporters in resistance to multiple drugs and stress response; phylogenetic classification of transporter proteins. Many scientific advances have been achieved in understanding physiological, biochemical, and molecular aspects of membrane proteins. Some have led to the design of new drugs with pharmacological importance; but this area of basic research is still wide open.

Invited
Lecturers
André Goffeau
University of Louvain-la-Neuf, Belgique
François Chaumont 
University of Louvain-la-Neuf, Belgique
Marcus Tamas
University of Gothenburg, Sweden
Margarida Archer
Universidade Nova de Lisboa
Paula Gonçalves 
Universidade Nova de Lisboa
Isabel João Soares-Silva
Universidade do Porto
Joana Sá-Pessoa
Queens University Ireland
Uminho
Lecturers
Margarida Casal (organizer)
Hernâni Gerós (organizer) 
Sandra Paiva
Artur Conde
Practical
Sessions Tutors
Gabriel Rocha
Henrique Noronha
David Ribas
João Silva
Department of Biology, University of Minho, Portugal
Topics
  • Biomembranes and transport: kinetics, energetics and molecular mechanisms
  • Bacterial membrane transport: from genes to proteins
  • Bacterial membrane transport: from proteins to molecular mechanism
  • Comparative genomics of yeasts membrane proteins and heterologous expression in Saccharomyces cerevisiae
  • The P-type proton transporting ATPases of Saccharomyces cerevisiae
  • The drug effluxers ATPases and permeases from Saccharomyces cerevisiae
  • The eukaryotic model system Aspergillus nidulans. Structure-fuction-specificity relationships in a model transporter
  • The Aspergillus nidulans UapA purine permease: signals & mechanisms of transporter endocytosis in fungi
  • Function and regulation of plant aquaporins: expression and activity measurements in plant cells
  • Plant aquaporins: regulation of trafficking and activity
  • Carboxylic acids transport in bacteria, yeast and mammalian cells – the wonderful world of crossing the edge
  • From microbes to Man: the transport of lactic acid and implications in cancer treatment
  • Xylose transport in yeasts: from the physiology to biotechnology
  • Glucose transport in yeasts
  • Endocytosis and intracellular trafficking of plasma membrane transporters

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