Centro de Biologia Molecular e Ambiental

Centre of Molecular and Environmental Biology

Mammalian and yeast cells as complementary cell models in Programmed Cell Death

Dates & Venue
June 17 - 28
Departament of Biology, Universidade do Minho
Ana Preto
CBMA-DB, University of Minho, Portugal
Cecília Rodrigues
Molecular Pathogenesis Centre, Faculty of Pharmacy, University of Lisbon, Portugal
Helena Vasconcelos Meehan
IPATIMUP-FF and REQUINTE-FF, University of Porto
Lucília Saraiva
IPATIMUP-FF and REQUINTE-FF, University of Porto
Manuela Côrte-Real
CBMA-DB, University of Minho, Portugal
Maria João Sousa
CBMA-DB, University of Minho, Portugal
Nadine Camougrand
Stéphen Manon
Susana Chaves
CBMA-DB, University of Minho, Portugal
Valdemar Máximo
IPATIMUP, University of Porto
Vítor Costa
IBMC, University of Porto
  • Programmed Cell Death processes versus necrosis
  • Apoptosis in mammalian cells
  • Programmed necrosis
  • Yeast apoptosis
  • Yeast as a tool for anticancer drug research
  • The central role of mitochondria in the intrinsic apoptotic pathway: mitochondrial membrane permeabilization mechanisms
  • Utilization of yeast to study the molecular aspects of the function of Bcl-2 family members
  • Autophagy in physiology and pathology
  • The role of autophagy in cancer
  • Mitophagy: from yeasts to mammalian cells
  • Features of cell death in neurodegenerative diseases
  • Evasion from programmed cell death in cancer and in cancer drug resistance. Pharmacological modulation of apoptosis as a therapeutic approach
  • Programmed cell death in mitochondrial pathologies: the tumor model
  • Sphingolipid signaling and oxidative stress in yeast cell death and ageing

  • It also includes a hands-on intensive module of lab work. In addition to brief descriptive lectures, the theoretical modules will entail discussions of scientific papers. The hands-on lab module will illustrate different aspects of the theoretical session topics, and will include different techniques to monitor morphological, biochemical and molecular changes associated to cell death processes and autophagy namely, epifluorescence microscopy and flow cytometry. They will be followed by results interpretation, group discussion and final wrap up.


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