CBMA

Centro de Biologia Molecular e Ambiental

Centre of Molecular and Environmental Biology

Mammalian and yeast as complementary cell models in Programmed Cell Death - 6th edition

Dates & Venue
June 22 to 3 July
Departament of Biology, Universidade do Minho
Invited Lecturers
Cecília Rodrigues
Molecular Pathogenesis Centre, Faculty of Pharmacy, University of Porto, Portugal
Clara Pereira
IBMC, University of Porto
Helena Vasconcelos Meehan
Faculty of Pharmacy and IPATIMUP, University of Porto
Lucília Saraiva
Pharmacy Faculty, University of Porto
Muriel Priault
CNRS-Université de Bordeaux, France
Nadine Camougrand
CNRS-Université de Bordeaux, France
Stéphen Manon
CNRS-Université de Bordeaux, France
Vítor Costa
IBMC, University of Porto

In-House
Lecturers
Ana Preto
CBMA-DB, University of Minho, Portugal
Manuela Côrte-Real
CBMA-DB, University of Minho, Portugal
Maria João Sousa
CBMA-DB, University of Minho, Portugal
Sara Alves
CBMA-DB, University of Minho, Portugal
Suellen Ferro
CBMA-DB, University of Minho, Portugal
Susana Chaves
CBMA-DB, University of Minho, Portugal

Topics

Programmed cell death processes versus necrosis

Apoptosis in mammalian cells

Programmed necrosis

Yeast apoptosis

Yeast as a model system to study apoptosis induced by anticancer drugs

The central role of mitochondria in the intrinsic apoptotic pathway: mitochondrial membrane permeabilization mechanisms

Utilization of yeast to study the molecular aspects of the function of Bcl-2 family members

Mitochondrial membrane permeabilization mechanisms

Utilization of yeast to study the molecular aspects of the function of Bcl-2 family members

Autophagy in physiology and pathology

The role of autophagy in cancer: the special case of the oncogene KRAS and colorectal carcinoma

Mitophagy: from yeasts to mammalian cells

Mitochondrial degradation during acetate–induced apoptosis in colorectal carcinoma cells

Biology of cell death in disease: an evolving interaction

Evasion from programmed cell death in cancer and in cancer drug resistance. Pharmacological modulation of apoptosis as a therapeutic approach.

Humanized yeast in cancer drug discovery: targeting p53 

Sphingolipid signaling and oxidative stress in yeast cell death and ageing

 Regulation of mitochondrial function and yeast lifespan by the phosphatase Sit4p

Pratical session
tutors
Catarina Afonso
CBMA-DB, University of Minho, Portugal
Cátia Pereira
CBMA-DB, University of Minho, Portugal

It also includes a hands-on intensive module of lab work. In addition to brief descriptive lectures, the theoretical modules will entail discussions of scientific papers. The hands-on lab module will illustrate different aspects of the theoretical session topics, and will include different techniques to monitor morphological, biochemical and molecular changes associated to cell death processes and autophagy namely, epifluorescence microscopy and flow cytometry. They will be followed by results interpretation, group discussion and final wrap up.

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